In:
Pediatric Transplantation, Wiley, Vol. 22, No. 1 ( 2018-02)
Abstract:
The incidence of death by CA after PHT x is unknown. We aimed to determine the incidence and factors for fatal CA after PHT x, and whether a PM affects survival. Retrospective cohort study utilizing the United Network of Organ Sharing registry of patients transplanted ≤18 years. Multivariable analyses in hazard‐function domain and Kaplan‐Meier analyses were performed for an outcome of death due to CA . There were 7719 PHT x patients queried. CA was the reported cause of death in 11%. Age ≥13 years at time of transplant, presence of a PM , and depressed EF were identified as significant factors for fatal CA . Death due to CA beyond 10 years post‐transplant was associated with depressed EF , CAV , and presence of a PM . Kaplan‐Meier analysis demonstrated higher likelihood of fatal CA in patients with CAV and in those with a PM vs those without. In total, 15% of patients with a PM died from CA . CA is a relatively common cause of death after PHT x. The benefit of a PM remains unclear, but its presence does not confer complete protection. Patients with associated factors warrant vigilant surveillance and consideration for retransplantation.
Type of Medium:
Online Resource
ISSN:
1397-3142
,
1399-3046
DOI:
10.1111/petr.2018.22.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2008614-3