In:
Pediatric Transplantation, Wiley, Vol. 24, No. 2 ( 2020-03)
Abstract:
Growth retardation is a common problem in children with CKD. This study aims to describe growth, prevalence of short stature before RTx, catch‐up growth after RTx, and associated factors. Methods We retrospectively reviewed 74 renal allograft recipients who underwent RTx at Fundación Cardioinfantil, Colombia, between January 2008 and September 2016 with follow‐up for 2 years afterwards. Pre‐RTx Height_SDS and demographic characteristics were compared between children with normal and short stature. Post‐RTx Height_SDS at 1 and 2 years post‐RTx and FAH, when available, were retrieved. Children were classified into catch‐up growth and no catch‐up growth groups depending on whether or not Height_SDS increased ≥0.5 per year within the first 2 years post‐RTx. Possible associated factors were compared. Results Seventy‐four patients were included. Mean age at RTx was 11 ± 4.0 years, and 43.2% (32/74) were females. Mean Height_SDS for the entire study population at pre‐RTx was −2.8 ± 1.5. Before RTx, 68.9% (51/74) had short stature, and 44.6% (33/74) had severe short stature. 37.2% presented catch‐up growth post‐RTx. Time on dialysis was associated with short pre‐RTx stature (OR 1.66; 95% CI [1.15‐2.39]; P = .006) and catch‐up growth (OR 2.15; 95% CI [1.15‐3.99]; P = .016). 44.59% (33/74) reached FAH, and 48.4% (16/33) presented short FAH. Conclusions Growth continues to be suboptimal after RTx. Given that pre‐RTx height is a significantly associated factor, it is important to plan early interventions in terms of growth improvement in these children.
Type of Medium:
Online Resource
ISSN:
1397-3142
,
1399-3046
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2008614-3
