In:
Pathology International, Wiley, Vol. 65, No. 3 ( 2015-03), p. 113-118
Abstract:
We classified ipsilateral breast tumor recurrences ( IBTR s) based on strict pathological rules. Ninety‐six women who were surgically treated for IBTR were included. IBTR s were classified according to their origins and were distinguished based on strict pathological rules: relationship between the IBTR and the primary lumpectomy scar, surgical margin status of the primary cancer, and the presence of in situ lesions of IBTR . The prognosis of these subgroups were compared to that of new primary tumors ( NP ) in the narrow sense ( NP n) that occurred far from the scar. Distant‐disease free survival of IBTR that occurred close to the scar with in situ lesions and a negative surgical margin of the primary cancer ( NP occurred close to the scar, NP cs) was similar to that of NP n. In contrast, IBTR that occurred close to the scar without in situ lesions (true recurrence ( TR ) that arose from residual invasive carcinoma foci, TR inv) had significantly poorer prognosis than NPn . IBTR that occurred close to the scar with in situ lesions and a positive surgical margin of the primary cancer ( TR arising from a residual in situ lesion, TR is) had more late recurrences than NP cs. Precise pathological examinations indicated four distinct IBTR subtypes with different characteristics.
Type of Medium:
Online Resource
ISSN:
1320-5463
,
1440-1827
DOI:
10.1111/pin.2015.65.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2008574-6