In:
Pathology International, Wiley, Vol. 67, No. 3 ( 2017-03), p. 131-140
Abstract:
A total of 313 cases of differentiated‐type early gastric adenocarcinomas, including 113 cases of small‐sized carcinoma (5 〈 × ≤10 mm) and 121 cases of microcarcinoma (0 〈 × ≤5 mm), were examined immunohistochemically to clarify the phenotypic expressions. They were classified into four categories (gastric phenotype (G‐type), intestinal phenotype, gastrointestinal phenotype, and null phenotype) by a two‐step process: the phenotype based on an immunoprofile of mucin core proteins (MUCs) with CDX2 (w/.CDX2‐assessment); and the phenotype of MUCs only (w/o.CDX2‐assessment). CDX2 expression was observed in 89.1% (279/313); it was highly expressed in 87.6% (106/121) of microcarcinomas. MUC2 expression increased as tumor size increased ( P 〈 0.05). Compared with w/o.CDX2‐assessment, w/.CDX2‐assessment showed significantly fewer G‐type carcinomas ( P 〈 0.05). Each phenotype marker was less expressed in the submucosal part than in the mucosal part. In conclusion, CDX2 was a sensitive marker for assessing intestinal phenotype. A large portion of the early differentiated‐type adenocarcinomas expressed CDX2 from the very early stage of carcinogenesis, and the proportion of G‐type was unexpectedly low. Lower expression of each phenotype marker was considered the cause of phenotype alteration during submucosal invasion.
Type of Medium:
Online Resource
ISSN:
1320-5463
,
1440-1827
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2008574-6
