In:
Journal of the Royal Statistical Society Series A: Statistics in Society, Oxford University Press (OUP), Vol. 181, No. 4 ( 2018-10-01), p. 1193-1209
Abstract:
Results obtained in randomized trials may not easily generalize to target populations. Whereas in randomized trials the treatment assignment mechanism is known, the sampling mechanism by which individuals are selected to participate in the trial is typically not known and assuming random sampling from the target population is often dubious. We consider an inverse probability of sampling weighted (IPSW) estimator for generalizing trial results to a target population. The IPSW estimator is shown to be consistent and asymptotically normal. A consistent sandwich-type variance estimator is derived and simulation results are presented comparing the IPSW estimator with a previously proposed stratified estimator. The methods are then utilized to generalize results from two randomized trials of human immunodeficiency virus treatment to all people living with the disease in the USA.
Type of Medium:
Online Resource
ISSN:
0964-1998
,
1467-985X
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2018
detail.hit.zdb_id:
204794-9
detail.hit.zdb_id:
1490715-X