In:
HLA, Wiley, Vol. 89, No. 5 ( 2017-05), p. 278-284
Abstract:
Type 1 diabetes ( T1D ) and celiac disease ( CeD ) are 2 distinct diseases, but there is an increased risk of developing CeD for T1D patients. Both diseases are associated with HLA ‐class II alleles, such as DQB1 *02:01 and DQB1 *03:02 ; however, their risk contribution vary between the diseases. Materials and Methods We genotyped HLA‐DRB1 and – DQB1 in 215 patients with coexisting T1D and CeD identified from a T1D cohort, and compared them to patients with T1D (N = 487) and CeD (N = 327), as well as healthy controls (N = 368). Results The patients with coexisting T1D and CeD had an intermediate carrier frequency (72.8%) of the DRB1 *03:01‐ DQB1 *02:01‐ DQA1 *05:01 haplotype compared to T1D (64.1%) and CeD (88.7%) patients. The DRB1 *03:01‐ DQB1 *02:01‐ DQA1 *05:01/ DRB1 *04‐ DQB1 *03:02‐ DQA1 *03 haplotype combination, encoding DQ2 .5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%). Conclusion Overall, the patients with coexisting T1D and CeD had an HLA profile more similar to T1D patients than CeD patients.
Type of Medium:
Online Resource
ISSN:
2059-2302
,
2059-2310
DOI:
10.1111/tan.2017.89.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2844321-4
