In:
Transfusion, Wiley, Vol. 55, No. 2 ( 2015-02), p. 388-394
Abstract:
Few studies were conducted on hepatitis B and C virus ( HBV and HCV , respectively) risk factors among C hinese blood donors in recent years since voluntary donors replaced commercial donors. Study Design and Methods A case‐control survey was conducted in HBV ‐ or HCV ‐positive and ‐negative donors from five blood centers in C hina between S eptember 2009 and A pril 2011. Case status was defined by having a reactive result on M onolisa HBsAg U ltra ( B io‐ R ad) for HBV and O rtho anti‐ HCV EIA 3.0 ( J ohnson & J ohnson) for HCV . Controls were randomly selected qualified blood donors matched to cases by donation month and blood center. Specific test‐seeking, medical‐related, and behavioral risk factors were compared by HBV and HCV status using chi‐square tests or F isher's exact tests with B onferroni correction. Results A total of 364 HBV cases, 174 HCV cases, and 689 controls completed the survey; response rates were 66.2, 47.3, and 82%, respectively. HCV ‐positive donors were significantly more likely to report having a blood transfusion history (23.4% vs. 3.0%, p 〈 0.0001) and ever living with a person with illegal drug injection (6.0% vs. 0.5%, p 〈 0.0001) than controls. Having intravenous and intramuscular injections in the past 12 months and ever having a tattoo are marginal risk factors for HCV (p values 〈 0.01). No specific risk factor for HBV was identified. Conclusion History of previous transfusion and living with illegal drug users are risk factors for HCV infection among C hinese blood donors from five regions. Test‐seeking behavior is not associated with HBV or HCV infections.
Type of Medium:
Online Resource
ISSN:
0041-1132
,
1537-2995
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2018415-3
