In:
The Journal of Physiology, Wiley, Vol. 594, No. 5 ( 2016-03), p. 1437-1449
Kurzfassung:
Erythropoietin is a neuroprotectant undergoing clinical trial for brain injury in term and preterm infants. This is the first experimental study to assess the acute effects of erythropoietin on the cerebral white matter in preterm ventilated lambs. Administration of erythropoietin within minutes of injurious ventilation onset amplified pro‐inflammatory cytokine gene expression in both the periventricular and subcortical white matter compared to the ventilation alone group; erythropoietin had no effect on the area of microglial aggregations in white matter regions with a reduction in cellular density of aggregations in the subcortical white matter only. Administration of erythropoietin in conjunction with injurious ventilation increased gene expression of tight junction proteins and reduced protein extravasation from blood vessels in the cerebral white matter. Given the increase in inflammation after erythropoietin, we recommend further investigation into its use as a treatment for ventilated preterm babies prior to clinical translation.
Materialart:
Online-Ressource
ISSN:
0022-3751
,
1469-7793
DOI:
10.1113/tjp.2016.594.issue-5
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
1475290-6
SSG:
12
