In:
The Journal of Physiology, Wiley, Vol. 594, No. 20 ( 2016-10-15), p. 5991-6008
Kurzfassung:
The cortical collecting duct (CCD) plays an essential role in sodium homeostasis by fine‐tuning the amount of sodium that is excreted in the urine. Ex vivo , the microperfused CCD reabsorbs sodium in the absence of lumen‐to‐bath concentration gradients. In the present study, we show that, in the presence of physiological lumen‐to‐bath concentration gradients, and in the absence of endocrine, paracrine and neural regulation, the mouse CCD secretes sodium, which represents a paradigm shift. This secretion occurs via the paracellular route, as well as a transcellular pathway that is energized by apical H + /K + ‐ATPase type 2 pumps operating as Na + /K + exchangers. The newly identified transcellular secretory pathway represents a physiological target for the regulation of sodium handling and for anti‐hypertensive therapeutic agents.
Materialart:
Online-Ressource
ISSN:
0022-3751
,
1469-7793
DOI:
10.1113/tjp.2016.594.issue-20
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
1475290-6
SSG:
12
