In:
The Journal of Physiology, Wiley, Vol. 597, No. 24 ( 2019-12), p. 5915-5933
Abstract:
Xenon (Xe) non‐competitively inhibited whole‐cell excitatory glutamatergic current ( I Glu ) and whole‐cell currents gated by ionotropic glutamate receptors ( I AMPA , I KA , I NMDA ), but had no effect on inhibitory GABAergic whole‐cell current ( I GABA ). Xe decreased only the frequency of glutamatergic spontaneous and miniature excitatory postsynaptic currents and GABAergic spontaneous inhibitory postsynaptic currents without changing the amplitude or decay times of these synaptic responses. Xe decreased the amplitude of both the action potential‐evoked excitatory and the action potential‐evoked inhibitory postsynaptic currents (eEPSCs and eIPSCs, respectively) via a presynaptic inhibition in transmitter release. We conclude that the main site of action of Xe is presynaptic in both excitatory and inhibitory synapses, and that the Xe inhibition is much greater for eEPSCs than for eIPSCs.
Type of Medium:
Online Resource
ISSN:
0022-3751
,
1469-7793
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1475290-6
SSG:
12