In:
The Journal of Physiology, Wiley, Vol. 546, No. 2 ( 2003-01), p. 455-460
Abstract:
Two forms of long‐term depression (LTD) of excitatory synaptic transmission have been identified in the mammalian CNS, which are induced by the synaptic activation of N ‐methyl‐ d ‐aspartate (NMDA) and metabotropic glutamate (mGlu) receptors, respectively. The mGlu receptor‐dependent form of LTD can be activated by application of 3,5‐dihydroxyphenylglycine (DHPG), a group I selective mGlu receptor agonist. DHPG‐induced LTD is increasingly being used to investigate the mechanisms of mGlu receptor‐dependent LTD. However, recent experiments have argued for both a pre‐ and postsynaptic locus of expression of DHPG‐induced LTD. In the present study we report that DHPG‐induced LTD is not associated with changes in the sensitivity of CA1 neurons to bath applied AMPA. Furthermore, in contrast to homosynaptic LTD, DHPG‐induced LTD is also not associated with changes in sensitivity to focally uncaged l ‐glutamate. These data do not support the notion that DHPG‐induced LTD requires a modification of AMPA receptors, such as their internalisation, but are compatible with a presynaptic mechanism of expression.
Type of Medium:
Online Resource
ISSN:
0022-3751
,
1469-7793
DOI:
10.1113/jphysiol.2002.033514
Language:
English
Publisher:
Wiley
Publication Date:
2003
detail.hit.zdb_id:
1475290-6
SSG:
12