In:
The Journal of Physiology, Wiley, Vol. 588, No. 12 ( 2010-06-15), p. 2133-2145
Abstract:
The establishment of neuronal networks in the brain is a complex but tightly controlled process involving several steps including the establishment and the maturation of synaptic contacts. Bassoon is a presynaptic scaffold protein which is amongst the first protein to appear at newly formed synapses. We have studied the properties of glutamatergic synapses in the hippocampus of mice mutated for bassoon during the first three weeks of postnatal development. Although synaptic transmission is not markedly affected at mature stages, we found that the lack of bassoon leads to functional defects at younger stages. Our study indicates that bassoon plays an important role in the proper functional maturation of presynaptic properties at these synapses. Moreover this work highlights the need to investigate the functional consequences of deleting synaptic genes not only at the adult stage, but also during the course of postnatal development.
Type of Medium:
Online Resource
ISSN:
0022-3751
,
1469-7793
DOI:
10.1113/tjp.2010.588.issue-12
DOI:
10.1113/jphysiol.2009.184929
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
1475290-6
SSG:
12
