In:
Journal of Biomechanical Engineering, ASME International, Vol. 131, No. 11 ( 2009-11-01)
Abstract:
A noninvasive method for estimating regional myocardial contractility in vivo would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. As a first step toward developing such a method, an explicit finite element (FE) model-based formal optimization of regional myocardial contractility in a sheep with left ventricular (LV) aneurysm was performed using tagged magnetic resonance (MR) images and cardiac catheterization pressures. From the tagged MR images, three-dimensional (3D) myocardial strains, LV volumes, and geometry for the animal-specific 3D FE model of the LV were calculated, while the LV pressures provided physiological loading conditions. Active material parameters (Tmax_B and Tmax_R) in the noninfarcted myocardium adjacent to the aneurysm (borderzone) and in the myocardium remote from the aneurysm were estimated by minimizing the errors between FE model-predicted and measured systolic strains and LV volumes using the successive response surface method for optimization. The significant depression in optimized Tmax_B relative to Tmax_R was confirmed by direct ex vivo force measurements from skinned fiber preparations. The optimized values of Tmax_B and Tmax_R were not overly sensitive to the passive material parameters specified. The computation time of less than 5 h associated with our proposed method for estimating regional myocardial contractility in vivo makes it a potentially very useful clinical tool.
Type of Medium:
Online Resource
ISSN:
0148-0731
,
1528-8951
Language:
English
Publisher:
ASME International
Publication Date:
2009
SSG:
31