In:
Science, American Association for the Advancement of Science (AAAS), Vol. 341, No. 6142 ( 2013-07-12), p. 186-191
Abstract:
The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium (Mg 2+ ) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg 2+ causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8 + T cells and impairs cytolytic responses against EBV. Notably, magnesium supplementation in MAGT1-deficient patients restores intracellular free Mg 2+ and NKG2D while concurrently reducing EBV-infected cells in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans. Moreover, these findings reveal a specific molecular function of free basal intracellular Mg 2+ in eukaryotic cells.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.1240094
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2013
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11