In:
Science, American Association for the Advancement of Science (AAAS), Vol. 212, No. 4490 ( 1981-04-03), p. 58-60
Kurzfassung:
Radioactive nitrogen-13 from nitrite (NO 2 - ) or nitrate (NO 3 - ) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells. We found rapid in vivo oxidation of NO 2 - to NO 3 - at concentrations of 2 to 3 nanomoles per liter in blood. Over 50 percent oxidation within 10 minutes accounted for the similar nitrogen-13 distributions from both parent ions. The oxidation rates were animal species-dependent. No reduction of 13 NO 3 - to 13 NO 2 - was observed. A mechanistic hypothesis invoking oxidation of 13 NO 2 - by a catalase-hydrogen peroxide complex accounts for the results. These results imply a concentration dependence for the in vivo fate of NO 2 - or nitrogen dioxide.
Materialart:
Online-Ressource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.7209517
Sprache:
Englisch
Verlag:
American Association for the Advancement of Science (AAAS)
Publikationsdatum:
1981
ZDB Id:
128410-1
ZDB Id:
2066996-3
ZDB Id:
2060783-0
SSG:
11