In:
Science, American Association for the Advancement of Science (AAAS), Vol. 346, No. 6216 ( 2014-12-19), p. 1456-1457
Abstract:
How do electric fields affect enzymatic processes? Binding and crystallographic studies have shown that electrostatic interactions are important in the substrate-binding step that initiates enzyme catalysis. However, for the subsequent steps, experimental data have been limited. The study of electric field effects on the transition state was therefore largely restricted to theory ( 1 ). On page 1510 of this issue, Fried et al. ( 2 ) use a recently developed technique to quantify the electrostatic contribution to the ratelimiting step of an enzymatic reaction. They show that the local electric field accelerates the reaction, a finding that is likely to apply to other catalytic reactions.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.aaa2878
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2014
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
