In:
Science, American Association for the Advancement of Science (AAAS), Vol. 351, No. 6275 ( 2016-02-19), p. 858-863
Abstract:
Dietary antigens are normally rendered nonimmunogenic through a poorly understood “oral tolerance” mechanism that involves immunosuppressive regulatory T (T reg ) cells, especially T reg cells induced from conventional T cells in the periphery (pT reg cells). Although orally introducing nominal protein antigens is known to induce such pT reg cells, whether a typical diet induces a population of pT reg cells under normal conditions thus far has been unknown. By using germ-free mice raised and bred on an elemental diet devoid of dietary antigens, we demonstrated that under normal conditions, the vast majority of the small intestinal pT reg cells are induced by dietary antigens from solid foods. Moreover, these pT reg cells have a limited life span, are distinguishable from microbiota-induced pT reg cells, and repress underlying strong immunity to ingested protein antigens.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.aac5560
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2016
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11