In:
Science, American Association for the Advancement of Science (AAAS), Vol. 367, No. 6477 ( 2020-01-31), p. 507-508
Abstract:
In the past decade, the understanding of cellular organization has undergone two major paradigm shifts. On the one hand, it was demonstrated that membrane-bound compartments exchange their contents not only through vesicular transport but also by means of direct membrane tethering at specific contact sites ( 1 ), revealing a new layer of connectivity in eukaryotic cells. On the other hand, the discovery of membraneless organelles, such as processing bodies (P-bodies) and stress granules, has revealed that proteins and RNAs can self-assemble and condense into liquid-like droplets through weak and multivalent interactions ( 2 ). This indicates that the cytosol is not a randomly dispersed soup of macromolecules but that it is subcompartmentalized. On page 527 of this issue, Lee et al. ( 3 ) bring these two exciting fields together by showing that a membrane-bound organelle, the endoplasmic reticulum (ER), contacts at least two membraneless compartments, P-bodies and stress granules, and influences their behavior.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.aba3771
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2020
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
