In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 3, No. 24 ( 2018-06-08)
Abstract:
In HIV + individuals receiving antiretroviral therapy, lymphoid tissues (LTs) that CD4 + T cells home to are a key site of HIV persistence. Studying the immune response to HIV in LTs has remained a challenge. By obtaining LTs from HIV + individuals, Buggert et al. have carried out comprehensive transcriptional and epigenetic analyses on CD8 + T cells in these LTs. They report that CD8 + T cells in LTs of HIV + individuals have a signature associated with resident memory T cells (T RMs ) and that the frequency of these HIV-responsive LT-resident CD8 + T cells was considerably increased in elite controllers. The study brings to the fore the importance of HIV-specific LT-resident T RMs in restraining HIV replication in LTs.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.aar4526
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2018