In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 6, No. 59 ( 2021-05-28)
Kurzfassung:
Germinal centers (GCs) are anatomic structures where B cells undergo affinity maturation, leading to production of high-affinity antibodies. The balance between T follicular helper (T FH ) and regulatory (T FR ) cells is critical for adequate control of GC responses. The study of human T FH and T FR cell development has been hampered because of the lack of in vitro assays reproducing in vivo biology, along with difficult access to healthy human lymphoid tissues. We used a single-cell transcriptomics approach to study the maturation of T FH and T FR cells isolated from human blood, iliac lymph nodes (LNs), and tonsils. As independent tissues have distinct proportions of follicular T cells in different maturation states, we leveraged the heterogeneity to reconstruct the maturation trajectory for human T FH and T FR cells. We found that the dominant maturation of T FR cells follows a bifurcated trajectory from precursor T reg cells, with one arm of the bifurcation leading to blood T FR cells and the other leading to the most mature GC T FR cells. Overall, our data provide a comprehensive resource for the transcriptomics of different follicular T cell populations and their dynamic relationship across different tissues.
Materialart:
Online-Ressource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abd8411
Sprache:
Englisch
Verlag:
American Association for the Advancement of Science (AAAS)
Publikationsdatum:
2021