In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 75 ( 2022-09-16)
Abstract:
Alveolar macrophages (AMs) are specialized macrophages that serve several key functions in the lung. Here, Dörr et al. used transcriptomic, ChIPmentation, and chromatin accessibility analysis to demonstrate that the transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is required for AM development. C/EBPβ-deficient AMs had defects in proliferation, lipid metabolism, and phagocytosis, thus causing mice to have symptoms that resemble pulmonary alveolar proteinosis (PAP). They observed that the long C/EBPβ protein variants LAP* and LAP, combined with CSF2 signaling, induced specific expression of Pparg isoform 2, which is a mechanism that they also observed in other CSF2-primed macrophages. These findings indicate that C/EBPβ is a key regulator of AM development and lipid metabolism.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abj0140
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
