In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 68 ( 2022-02-11)
Abstract:
IL-2 is known to play multiple roles during the generation of effector and memory CD8 T cell responses. Here, Kahan et al. show that a subset of CD8 T cells with the capacity to intrinsically express IL-2 has stem-like features, displays a memory phenotype, can resist exhaustion, and controls chronic viral infection. This cell-intrinsic expression of IL-2 attenuates responses to IL-2–dependent STAT5 signaling and limits terminal effector generation, which allows for more effective protection. In contrast, CD8 effector T cells that do not intrinsically produce IL-2 develop effector traits and show less memory formation. These two subsets eventually coalesce as the memory transition progresses. These findings indicate that intrinsic IL-2 production during the effector phase contributes to the protective capacity of CD8 T cells.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abl6322
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
