In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 69 ( 2022-03-25)
Kurzfassung:
While regulatory T cells (T regs ) are critical for maintaining immune tolerance, their suppressive functions must be temporarily overcome to generate productive immune responses against pathogens and tumors. Teh et al . demonstrate that caspase-8 regulates T reg homeostasis by tuning their susceptibility to inflammatory cell death. Caspase-8–deficient T regs were protected against apoptotic cell death during homeostasis but were more susceptible to MLKL-dependent necroptotic cell death during chronic viral infection. Human T regs were also more sensitive to necroptosis induced by caspase inhibition than conventional T cells. While caspase-8 in T regs functioned to prevent lethal inflammation, it also antagonized antiviral and antiparasitic immunity, highlighting a key regulatory mechanism in controlling the balance between immunity and pathologic inflammation.
Materialart:
Online-Ressource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abn8041
Sprache:
Englisch
Verlag:
American Association for the Advancement of Science (AAAS)
Publikationsdatum:
2022
