In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 72 ( 2022-06-24)
Abstract:
CMV-based vaccine vectors for simian immunodeficiency virus (RhCMV/SIV) lead to profound protection against SIV in rhesus macaques (RMs). This protection is related to the induction of MHC-II– and MHC-E–targeting CD8 + T cells, but it is unclear how these unconventional cells are primed and which are needed for protection. Here, Hansen et al. used microRNAs to limit the ability of RhCMV/SIV vectors to replicate in various cell types. They found that limiting RhCMV/SIV vaccine replication in myeloid cells abrogated the induction of MHC-E–restricted T cells and protection against SIV of in RMs. These data suggest that the unconventional, MHC-E–restricted CD8+ T cells induced by RhCMV/SIV are critical for protection against SIV.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abn9301
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022