In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 69 ( 2022-03-25)
Abstract:
The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) caused an unprecedented rise in COVID-19 cases, even among vaccinated individuals. Omicron has a high number of mutations in the spike protein, probably aiding its evasion of immune responses. GeurtsvanKessel et al. studied humoral and cellular immune responses to Omicron and other VOCs to understand how vaccinated individuals are protected against Omicron. They found that antibody cross-neutralization of Omicron was very low or absent compared with WT, Beta, and Delta variants, but could be partially restored by a third booster vaccination. T cells recognized Omicron just as effectively as other VOCs, suggesting that vaccinated individuals maintain T cell immunity, which could provide protection in the absence of neutralizing antibodies, limiting severe disease.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abo2202
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022