In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 8, No. 80 ( 2023-02-24)
Abstract:
Effective human immunity to mycobacteria depends on IFN-γ made by lymphocytes. IL-12 and IL-23 are related cytokines that contribute to induction of IFN-γ-producing lymphocytes. Philippot et al . screened a large cohort of patients diagnosed with diverse infectious diseases and identified six patients from four families who were homozygous for loss-of-function alleles of the IL-23 receptor (IL-23R) and had a history of mycobacterial disease. In vitro activation studies of blood lymphocytes from these IL-23R-deficient patients and healthy controls revealed a marked defect in IFN-γ production by natural killer cells and two innate-like adaptive T cell subsets in IL-23R-deficient individuals. These new findings reveal that IL-23 is an essential driver of IFN-γ synthesis by multiple innate-like lymphocyte subsets that contribute to host protection from mycobacterial disease.—IRW
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abq5204
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023