In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 8, No. 83 ( 2023-05-26)
Abstract:
Although selective immunoglobin A (IgA) deficiency (SIgAD) is the most common primary human immunodeficiency, the apparently asymptomatic nature of SIgAD in many patients has prompted uncertainty about how necessary IgA is for homeostatic regulation of the commensal gut microbiota. Using a combination of bacterial flow cytometry and 16 S rRNA sequencing, Conrey et al . analyzed secretory and systemic antibody binding to fecal bacteria in a cohort of pediatric patients with SIgAD and their sibling controls. Patients with SIgAD lacking both serum and fecal IgA had higher concentrations of serum IgG reactive with gut bacteria than patients with SIgAD who retained some fecal IgA. These findings indicate that combined loss of systemic and secretory IgA amplifies systemic exposure to gut bacteria, leading to a higher incidence of systemic immune dysregulation. —Ifor R. Williams
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.ade2335
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023