In:
Science Signaling, American Association for the Advancement of Science (AAAS), Vol. 16, No. 778 ( 2023-03-28)
Abstract:
Internal tandem duplication of Fms-like tyrosine kinase 3 (FLT3-ITD) is a common activating mutation in acute myeloid leukemia (AML) and leads to the increased production of reactive oxygen species (ROS). AML patients on FLT3-targeting therapies have a high rate of relapse. By performing a proteome-wide analysis of cysteine oxidation and phosphorylation of AML blast cells from patients harboring FLT3 mutations, Germon et al . identified the Rac-NOX2 complex as a driver of ROS production in AML cells. Inhibition of NOX2 promoted apoptosis of AML cells carrying the FLT3-ITD mutation and increased the survival of mice grafted with FLT3-ITD AML cells and treated with FLT3 inhibitors. Thus, targeting NOX2 may increase the effectiveness of precision therapy targeting AML. —AB
Type of Medium:
Online Resource
ISSN:
1945-0877
,
1937-9145
DOI:
10.1126/scisignal.abp9586
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023