In:
Science Signaling, American Association for the Advancement of Science (AAAS), Vol. 16, No. 793 ( 2023-07-11)
Kurzfassung:
Neutrophils are recruited to sites of injury and infection by various factors, including lipids called eicosanoids, and can adopt a proinflammatory N1 phenotype or an anti-inflammatory N2 phenotype. Maus et al . found that an eicosanoid subtype called oxoeicosanoids enhanced wound healing and reduced the susceptibility to sepsis in mice due to an increase in N2 neutrophil recruitment. Oxoeicosanoids promoted N2 polarization through autocrine activation of the oxoeicosanoid receptor OXER1. These findings suggest potential strategies for manipulating neutrophil polarization to improve clinical outcomes. —Annalisa M. VanHook
Materialart:
Online-Ressource
ISSN:
1945-0877
,
1937-9145
DOI:
10.1126/scisignal.add6527
Sprache:
Englisch
Verlag:
American Association for the Advancement of Science (AAAS)
Publikationsdatum:
2023
