In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 711 ( 2023-08-30)
Abstract:
Aging is associated with increased muscle weakness, which has been tied to reduced abundance of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). Here, Bae and colleagues used high-throughput screening to identify farnesol as an inducer of PGC-1α. Farnesol administration led to improved muscle capacity and strength in aged mice, as well as improved regeneration after injury, through a mechanism involving farnesylation of PARIS (Parkin-interacting substrate), which is a known transcriptional suppressor of PGC-1α. These preclinical findings suggest that farnesol might be useful to treat muscle weakness associated with aging or diseases that decrease PGC-1α. —Melissa Norton
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abh3489
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023