In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 633 ( 2022-02-23)
Abstract:
Neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), have been associated to epigenetic modifications, suggesting that identification of specific epigenetic patterns could provide insights into disease pathophysiology and help the identification of potential pharmacological targets. Here, Hop et al. analyzed DNA methylation pattern, one of the most characterized epigenetic modifications, in almost 10,000 individuals with ALS and controls and identified 45 differentially methylated positions (DMPs) annotated to 42 genes. The changes involved genes associated to metabolic and inflammatory pathways, and the authors identified several DMPs associated with disease progression in their cohort. The results will help the identification of disease-relevant mechanisms that could be targeted to block or delay ALS progression.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abj0264
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022