In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 645 ( 2022-05-18)
Abstract:
Regulatory T cells (T regs ) are a well-known marker of cancer progression, and the tumor-derived cytokine thymic stromal lymphopoietin (TSLP) is thought to influence the function of T regs in the tumor microenvironment. Here, Obata-Ninomiya et al. examine this relationship in the context of colitis-associated colorectal cancer (CRC) tumorigenesis. They saw T regs expressing the receptor for TSLP that were enriched in the peripheral blood and tumors of patients and mice with CRC. They treated a chemically induced CRC mouse model with TSLP monoclonal antibodies that inhibited the progression of CRC. TSLP represents a potential therapeutic target to regulate T reg function and control CRC progression.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abl6960
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
