In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 638 ( 2022-03-30)
Abstract:
Chorioamnionitis is a potentially fatal inflammatory condition of the fetus caused by inflammation of the chorion and/or amnion and is linked to a large fraction of preterm births and an elevated risk for respiratory disease in childhood and adulthood. Toth et al. describe the development of a prenatal rhesus macaque ( Macaca mulatta ) model that used intra-amniotic lipopolysaccharide (LPS) challenge to induce experimental chorioamnionitis. This model mirrored structural and temporal changes consistent with prenatal human lung development. LPS challenge resulted in extensive damage to alveolar structures that resembled chronic lung disease in newborns, and single-cell RNA sequencing analysis showed marked disruption of alveologenesis signals. Intrauterine blockade of IL-1β and TNFα ameliorated inflammatory responses and restored lung integrity. These findings highlight the relevance of a nonhuman primate model for understanding and developing treatments for chorioamnionitis.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abl8574
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
