In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 634 ( 2022-03-02)
Kurzfassung:
Defective lymphatic vessel valve development impairs lymphatic fluid flow and contributes to lymphatic malformations, lymphedema, and related lymphatic disorders. Here, Byrne et al. identified mutations in MDFIC associated with impairments in truncal collecting lymphatic vessels in individuals with central conducting lymphatic anomaly. Mdfic variants disrupted lymphatic vessel patterning and valve development in mouse models, and in vitro work identified how MDFIC regulates integrin activation and collective cell migration. This work highlights the importance of lymphatic valve development and adds to our understanding of the molecular mechanisms underlying lymphatic disorders.
Materialart:
Online-Ressource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abm4869
Sprache:
Englisch
Verlag:
American Association for the Advancement of Science (AAAS)
Publikationsdatum:
2022
