In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 641 ( 2022-04-20)
Abstract:
Breakthrough infections with SARS-CoV-2 have increased in frequency due to both waning immunity and emergence of variants. For example, a cluster of breakthrough infections with the delta variant occurred in a highly vaccinated population in Provincetown, Massachusetts in July 2021. Here, Collier et al. characterized the humoral and cellular immune responses in vaccinated individuals from Provincetown who did or did not develop a breakthrough case of SARS-CoV-2. Vaccinated individuals that tested positive for SARS-CoV-2 had increased mucosal and serum antibody responses, as well as boosted CD8 + T cell responses relative to those who were not infected. Together, these results suggest that, through both vaccination and breakthrough infections, population-level immunity to SARS-CoV-2 will continue to increase.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abn6150
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022