In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 660 ( 2022-08-31)
Kurzfassung:
Reduced gut microbial diversity after allogeneic stem cell transplantation has been associated with decreased survival, but the role of the gut microbiome after solid organ transplantation is not as well studied. Here, Swarte and colleagues studied dysbiosis of the gut microbiome in a large cohort of individuals with end-stage liver or kidney disease before and after organ transplantation. Transplant recipients suffered from gut dysbiosis, with lower diversity and increased abundance of unhealthy species, virulence factors, and antibiotic resistance genes. Furthermore, immunosuppressive drug use was associated with dysbiosis, and increased dysbiosis was associated with increased mortality after transplantation. These results suggest that microbiome-targeted interventions could potentially affect outcomes after solid organ transplantation.
Materialart:
Online-Ressource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abn7566
Sprache:
Englisch
Verlag:
American Association for the Advancement of Science (AAAS)
Publikationsdatum:
2022
