In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 678 ( 2023-01-11)
Abstract:
The common γ chain (γc; IL-2RG) is a component of cytokine receptors specific to the γc cytokine family that includes IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Studies of the γc cytokines have been constrained by the lack of a neutralizing antibody that can recognize IL-2RG. Le Floc’h et al . describe the generation and characterization of REGN7257, a monoclonal antibody specific to IL-2RG. In vitro studies confirmed that REGN7257 binds with high affinity to IL-2RG and specifically blocks γc cytokine signaling. Treatment of nonhuman primates with REGN7257 suppressed NK cells and T cells without affecting granulocytes, erythrocytes, or platelets. Interestingly, REGN7257 curbed pathogenic responses in mouse models of allogeneic and xenogeneic graft-versus-host-disease, immune aplastic anemia, and multiple sclerosis, thus confirming the critical role of the γc cytokines in these immune mediated disorders.—CNF
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abo0205
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2023