In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 671 ( 2022-11-16)
Abstract:
Chemotherapy lowers blood neutrophils and results in fever in some patients. Schwabkey et al . found that the gut microbiome may promote the onset of such neutropenic fever. Transferring gut microbiota from patients with neutropenic fever to irradiated mice promoted the development of subsequent fever. An excess of mucin-degrading Akkermansia bacteria found in the transferred microbiomes of febrile patients, as well as in nontransplanted but irradiated or chemotherapy-treated mice that reduced their food intake, resulted in a compromised intestinal barrier in mice that could be circumvented by administration of propionate. This study thus ties alterations in the gut microbiome to neutropenic fever and may provide a potential therapeutic strategy.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.abo3445
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022