In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 692 ( 2023-04-19)
Kurzfassung:
Correlates of protection are immunological markers, such as quantity of antibodies, that associate with the level of vaccine protection. Identifying such correlates is important for measuring the performance of vaccines. Here, Benkeser et al . aimed to identify the best correlates of protection against COVID-19 in recipients of the mRNA-1273 vaccine. Using immune markers including live virus neutralizing antibody titers in samples from participants of the COVE mRNA-1273 vaccine efficacy trial, the authors found that a single pseudovirus neutralizing antibody titer or a single spike protein–binding antibody concentration was the best correlate of protection for the vaccine. Higher pseudovirus neutralizing antibody titers and higher spike protein–binding antibody concentrations associated with greater vaccine protection from COVID-19. Together, these data will help to guide future vaccine development and will aid in immunobridging studies. —CM
Materialart:
Online-Ressource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.ade9078
Sprache:
Englisch
Verlag:
American Association for the Advancement of Science (AAAS)
Publikationsdatum:
2023