In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 15, No. 707 ( 2023-08-02)
Kurzfassung:
Identifying factors that restrict human immunodeficiency virus (HIV)–1 replication in vivo may inform potential cure strategies for people living with HIV-1. Here, Geretz et al . analyzed transcripts from both the host and virus within the same single cells to identify host transcripts associated with lower HIV-1 RNA. Using samples from a person living with HIV-1, the authors identified prothymosin α as one such host restriction factor, which they validated in 28 additional participants. Further, overexpression of prothymosin α was sufficient to restrict HIV-1 replication in vitro. These data demonstrate that prothymosin α is a host restriction factor and suggest that it may represent a target for HIV-1 cure strategies. —Courtney Malo
Materialart:
Online-Ressource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.adg0873
Sprache:
Englisch
Verlag:
American Association for the Advancement of Science (AAAS)
Publikationsdatum:
2023