In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 64, No. 7 ( 2020-06-23)
Kurzfassung:
Anidulafungin and micafungin were quantified in cerebrospinal fluid (CSF) of critically ill adults and in cerebral cortex of deceased patients. In CSF, anidulafungin levels ( 〈 0.01 to 0.66 μg/ml) and micafungin levels ( 〈 0.01 to 0.16 μg/ml) were lower than those in plasma concentrations (0.77 to 5.07 and 1.21 to 8.70 μg/ml, respectively) drawn simultaneously. In cerebral cortex, anidulafungin and micafungin levels were 0.21 to 2.34 and 0.18 to 2.88 μg/g, respectively. Thus, MIC values of several pathogenic Candida strains exceed concentrations in CSF and in brain.
Materialart:
Online-Ressource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.00275-20
Sprache:
Englisch
Verlag:
American Society for Microbiology
Publikationsdatum:
2020
ZDB Id:
1496156-8
SSG:
12
SSG:
15,3