In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 53, No. 11 ( 2009-11), p. 4927-4929
Kurzfassung:
The efficacy of ATP synthase inhibitor TMC207 was assessed in early and late Mycobacterium avium infections in mice. In contrast to what was earlier observed for M. tuberculosis , a bacteriostatic effect was obtained. In vitro, the minimal bactericidal concentration (MBC)/MIC ratio was very high. The MBC was more relevant for assessment of pharmacokinetic/pharmacodynamic relationships than the MIC.
Materialart:
Online-Ressource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.00689-09
Sprache:
Englisch
Verlag:
American Society for Microbiology
Publikationsdatum:
2009
ZDB Id:
1496156-8
SSG:
12
SSG:
15,3
