In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 53, No. 1 ( 2009-01), p. 306-308
Abstract:
This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis . The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.01346-07
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2009
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3