In:
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 41, No. 5 ( 1997-05), p. 1162-1165
Abstract:
The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible strain. In 13 isolates and the 4 laboratory mutants, cross-resistance to macrolides, lincosamides, and B-type streptogramins was associated with an A-- 〉 G transition at a position cognate with Escherichia coli 23S rRNA base 2058. These strains were resistant to 〉 or = 512 microg of erythromycin per ml. Two other mutations were identified, an A-- 〉 G transition at base 2059 in seven strains, associated with high-level resistance to all macrolides, and a G-- 〉 A transition at base 2057 in six strains, associated with low-level resistance to erythromycin. These mutations correspond to three of four phenotypic classes previously identified by using MIC determinations.
Type of Medium:
Online Resource
ISSN:
0066-4804
,
1098-6596
DOI:
10.1128/AAC.41.5.1162
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
1997
detail.hit.zdb_id:
1496156-8
SSG:
12
SSG:
15,3