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Mutations in the gyrA , parC , and parE Genes Associated with Fluoroquinolone Resistance in Clinical Isolates of Mycoplasma hominis

Bebear, Cécile M. ; Renaudin, Joel ; Charron, Alain ; [et al.]

American Society for Microbiology ; 1999

In: Antimicrobial Agents and Chemotherapy Vol. 43, No. 4 ( 1999-04), p. 954-956

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In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 43, No. 4 ( 1999-04), p. 954-956

Abstract: Five clinical isolates of Mycoplasma hominis from three different patients were examined for resistance to fluoroquinolones; some of these isolates were probably identical. All five isolates harbored amino acid substitutions in the quinolone resistance-determining regions of both DNA gyrase (GyrA) and topoisomerase IV (ParC or ParE). Furthermore, the novobiocin MIC for three isolates showed a significant increase. This is the first characterization of fluoroquinolone-resistant clinical mycoplasma isolates from humans.

Type of Medium: Online Resource

ISSN: 0066-4804 , 1098-6596

URL: Article

DOI: 10.1128/AAC.43.4.954

RVK:

XA 24552

Language: English

Publisher: American Society for Microbiology

Publication Date: 1999

detail.hit.zdb_id: 1496156-8

SSG: 12

SSG: 15,3