KOBV Portal

Hits per page

hit 1 - 1 | 1 hit

Select All Export

Online Resource

The Immunologically Distinct O Antigens from Francisella tularensis Subspecies tularensis and Francisella novicida Are both Virulence Determinants and Protective Antigens

Thomas, Rebecca M. ; Titball, Richard W. ; Oyston, Petra C. F. ; [et al.]

American Society for Microbiology ; 2007

In: Infection and Immunity Vol. 75, No. 1 ( 2007-01), p. 371-378

add to watchlist on the watchlist

Details

In: Infection and Immunity, American Society for Microbiology, Vol. 75, No. 1 ( 2007-01), p. 371-378

Abstract: We have determined the sequence of the gene cluster encoding the O antigen in Francisella novicida and compared it to the previously reported O-antigen cluster in Francisella tularensis subsp. tularensis . Immunization with purified lipopolysaccharide (LPS) from F. tularensis subsp. tularensis or F. novicida protected against challenge with Francisella tularensis subsp. holarctica and F. novicida , respectively. The LPS from F. tularensis subsp. tularensis did not confer protection against challenge with F. novicida , and the LPS from F. novicida did not confer protection against challenge with F. tularensis subsp. holarctica . Allelic replacement mutants of F. tularensis subsp. tularensis or F. novicida which failed to produce O antigen were attenuated, but exposure to these mutants did not induce a protective immune response. The O antigen of F. tularensis subsp. tularensis appeared to be important for intracellular survival whereas the O antigen of F. novicida appeared to be critical for serum resistance and less important for intracellular survival.

Type of Medium: Online Resource

ISSN: 0019-9567 , 1098-5522

URL: Article

DOI: 10.1128/IAI.01241-06

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2007

detail.hit.zdb_id: 1483247-1