In:
Infection and Immunity, American Society for Microbiology, Vol. 69, No. 12 ( 2001-12), p. 7603-7609
Kurzfassung:
We used a panel of nine fusion proteins that contain different Duffy binding-like α (DBL-α) domains of Plasmodium falciparum -infected erythrocyte membrane protein 1 to assess the levels of antibody activity in serum samples obtained from semi-immune or nonimmune individuals from Lambaréné, Gabon. Recognition was measured in terms of either the prevalence or the magnitude of the response. A strong correlation between the immune status of the patients and reactivity with recombinant proteins was observed, which was interpreted as a reflection of the number of infections acquired over time. The antibody responses were predominantly directed toward variable epitopes of the DBL-α domain. Antibody responses could be reduced by preincubation of the sera with various fusion proteins. A portion of individuals who exhibited high-level responses to all fusion proteins also had antibodies which recognized conserved epitopes. The possibility that a synergizing effect of anti-DBL-α domain antibodies could support chemotherapy is discussed.
Materialart:
Online-Ressource
ISSN:
0019-9567
,
1098-5522
DOI:
10.1128/IAI.69.12.7603-7609.2001
Sprache:
Englisch
Verlag:
American Society for Microbiology
Publikationsdatum:
2001
ZDB Id:
1483247-1
