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T Cells That React to the Immunodominant Leishmania major LACK Antigen Prevent Early Dissemination of the Parasite in Susceptible BALB/c Mice

Schilling, Sabrina ; Petri, W. A. ; Glaichenhaus, Nicolas

American Society for Microbiology ; 2001

In: Infection and Immunity Vol. 69, No. 2 ( 2001-02), p. 1212-1214

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In: Infection and Immunity, American Society for Microbiology, Vol. 69, No. 2 ( 2001-02), p. 1212-1214

Abstract: Susceptibility of BALB/c mice to Leishmania major depends on the early production of IL-4 by CD4 + T cells which react to the parasite LACK antigen. Here, we show that LACK-specific cells are rapidly recruited to the site of infection and favor the early dissemination of L. major to the internal organs.

Type of Medium: Online Resource

ISSN: 0019-9567 , 1098-5522

URL: Article

DOI: 10.1128/IAI.69.2.1212-1214.2001

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2001

detail.hit.zdb_id: 1483247-1