In:
Journal of Bacteriology, American Society for Microbiology, Vol. 187, No. 9 ( 2005-05), p. 3282-3286
Kurzfassung:
Transcription of the Escherichia coli osmB gene is induced by several stress conditions. osmB is expressed from two promoters, osmBp1 and osmBp2 . The downstream promoter, osmBp2 , is induced after osmotic shock or upon entry into stationary phase in a σ S -dependent manner. The upstream promoter, osmBp1 , is independent of σ S and is activated by RcsB, the response regulator of the His-Asp phosphorelay signal transduction system RcsCDB. RcsB is responsible for the induction of osmBp1 following treatment with chlorpromazine. Activation of osmBp1 by RcsB requires a sequence upstream of its −35 element similar to the RcsB binding site consensus, suggesting a direct regulatory role. osmB appears as another example of a multistress-responsive gene whose transcription involves both a σ S -dependent promoter and a second one independent of σ S but controlled by stress-specific transcription factors.
Materialart:
Online-Ressource
ISSN:
0021-9193
,
1098-5530
DOI:
10.1128/JB.187.9.3282-3286.2005
Sprache:
Englisch
Verlag:
American Society for Microbiology
Publikationsdatum:
2005
ZDB Id:
1481988-0
SSG:
12
