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Mutation Detection and Accurate Diagnosis of Extensively Drug-Resistant Tuberculosis: Report from a Tertiary Care Center in India

Ajbani, Kanchan ; Rodrigues, Camilla ; Shenai, Shubhada ; [et al.]

American Society for Microbiology ; 2011

In: Journal of Clinical Microbiology Vol. 49, No. 4 ( 2011-04), p. 1588-1590

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In: Journal of Clinical Microbiology, American Society for Microbiology, Vol. 49, No. 4 ( 2011-04), p. 1588-1590

Abstract: We screened and spoligotyped 150 consecutive phenotypically confirmed extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) isolates (January 2008 to March 2009) for rifampin, isoniazid, fluoroquinolone, and aminoglycoside resistance targeting rpoB , inhA , katG , gyrA , gyrB , and rrs . Mutations predominant among XDR-TB were S315T ( katG ) (100% of isolates), S531L ( rpoB ) (97% of isolates), D94G ( gyrA ) (53% of isolates), and A1401G ( rrs ) (71% of isolates). Spoligotyping revealed 62% of the isolates to be Beijing.

Type of Medium: Online Resource

ISSN: 0095-1137 , 1098-660X

URL: Article

DOI: 10.1128/JCM.00113-11

RVK:

XA 10000

Language: English

Publisher: American Society for Microbiology

Publication Date: 2011

detail.hit.zdb_id: 1498353-9

SSG: 12